![]() ![]() That same year, he submitted a landscape painting to the Salon and was accepted. The city became a glittering stage for modern advancements and bourgeois pleasure, which paved the way for a new kind of subject that was eagerly adopted by the Impressionists and artistic avant-garde.īorn in Paris in 1850, Raffaëlli first studied theater and music before turning to painting in 1870. At the request of Emperor Napoleon III, Haussmann designed and carried out a large-scale urban renewal program, erecting landmarks and tree-lined thoroughfares throughout the city to create a unified and socially-centered urban aesthetic. On the whole, it was an entirely new kind of painting, and it was largely influenced by the work of social engineer Baron Haussmann beginning in the 1850s. Camille Pissarro, Claude Monet, Gustave Caillebotte and others composed significant works on the subject of the urban milieu. Raffaëlli was not the only artist of his era to devote his canvases to the urban landscape. Perhaps more aligned with Naturalism than Impressionism, the visual effect of Raffaëlli's composition is one of carefully composed spontaneity that makes manifest the joie de vivre of the age. His figures exude a sense of being suspended in time, as though they are part of some subtle narrative that is both restless and harmonious. While Raffaëlli was never fully accepted as a member of the Impressionist group, his works display a similar affinity for capturing the transient moments of modern life. His legacy documents the realities of urban life during his age, all chronicled in his distinctive brushwork and sophisticated palette. Exploring the climate of the city, Raffaëlli's mature works capture the energy of the grand parks and boulevards of the new Paris that emerged at the turn of the century. The delicate oil captures a familiar subject from late 19th-century life in the city: a busy avenue at the edge of a park on a cool autumn day. This thoroughly modern Parisian scene was composed by the celebrated French painter Jean François Raffaëlli. Today, his works reside in prestigious institutions such as the British Museum (London) and the Walters Museum (Baltimore). Additionally, he was well-decorated at the grand exhibitions of the day, earning medals at the Salons of 18, a bronze medal at the 1889 Exposition Universelle and a gold medal at the 1900 Exposition Universelle, demonstrating his position as one of the most accomplished artists of the Belle Époque. In 1900, he was named a Chevalier of the Legion d'Honneur and an Officer in 1909. The artist was associated with practically all of the most influential artists and thinkers of late 19th century France, including Édouard Manet, Edgar Degas, Émile Zola, who frequently met at the legendary Cafe de la Nouvelle Athenes to share their thoughts on modern society. Although he began his career painting dark-toned realist compositions, by 1890, his style had shifted to what would become his signature - a lighter, brighter, idealistic society world. Despite his lack of Academy training, he made his debut at the Paris Salon of 1875 with a sculptural medallion and etchings, and he exhibited his first painting at the Salon of 1881. This was the only formal art training La Touche would ever receive. ![]() At ten years old, he began taking private art instruction, which lasted until 1870, when his family was forced to flee to Normandy amid the Franco-Prussian War. Cloud, outside of Paris, in 1854, and he showed a keen interest in art from a young age. However, La Touche's style is singular, possessing an element of fantasy and romance that set him apart from the Impressionists. Such relaxed, inviting scenes were remarkably popular among contemporary, modern audiences. The scene is an informal one, and its unconventional cropping suggests that the viewer is invited to take a seat in the boat and join the group on their outing. The subject also recalls works by Manet, Monet and Renoir, who delighted in depictions of modern leisure among the expanding middle class. Set against the plein air backdrop of a wooded pond awash in the soft glow of the golden hour, the scene reflects the influence of the Impressionists. ![]() With its luminous coloring and feathery brushwork, this oil evokes the style and joie de vivre of the era rendered in La Touche’s distinctive, mature style.įresh and airy, the work is a beautiful example of the artist’s skill at capturing the subtle qualities of light and color. Softly lit and lushly detailed, the work represents the artist’s talent for capturing the gaiety of the Belle Époque. A fashionable group of merrymakers boards a rowboat at sundown in this oil on panel by renowned French painter Gaston La Touche. ![]()
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![]() ![]() ![]() Legends are especially useful when multiple lines, markers, or colors are used in a plot, as they provide a visual guide to understand the meaning behind these graphical representations. The simplest way to create a legend is by using the plt.legend() command, which automatically generates a legend for labeled plot elements. Let’s delve into the details of how you can create, display, and perform various actions with legends. To further expand your understanding of Python programming, don’t hesitate to explore additional tutorials available at Python Programming Tutorials. In this tutorial, we will learn how to add a legend to a Matplotlib plot in Python and customization of legends, thereby enhancing the overall clarity and interpretability of your graphs. Particularly, when dealing with graphs that contain multiple lines of varying colors, legends play a crucial role in clarifying the meaning behind these color-coded lines. As a powerful 2D plotting library, it allows you to input arrays of numbers and plot the data in various graphical representations, including bar graphs, histograms, scatter plots, and line plots. Of instance to Handler as a keyword to legend.Matplotlib is a widely used Python package for data visualization. ![]() On the legend() function for convenience). Which accepts a numpoints argument (numpoints is also a keyword Sake of simplicity, let's choose legend_handler.HandlerLine2D The simplest example of using custom handlers is to instantiate one of theĮxisting legend_handler.HandlerBase subclasses. With the value in the handler_map keyword.Ĭheck if the handle is in the newly created handler_map.Ĭheck if the type of handle is in the newly created handler_map.Ĭheck if any of the types in the handle's mro is in the newlyįor completeness, this logic is mostly implemented inĪll of this flexibility means that we have the necessary hooks to implementĬustom handlers for our own type of legend key. The choice of handler subclass is determined by the following rules: In order to create legend entries, handles are given as an argument to an legend ( handles =, loc = 'lower right' ) plt. add_artist ( first_legend ) # Create another legend for the second line. legend ( handles =, loc = 'upper right' ) # Add the legend manually to the Axes. plot (, label = "Line 2", linewidth = 4 ) # Create a legend for the first line. plot (, label = "Line 1", linestyle = '-' ) line2, = ax. To keep old legend instances, we must add themįig, ax = plt. To call legend() repeatedly to update the legend to the latest This has been done so that it is possible ![]() The legend() function multiple times, you will find that only one Whilst the instinctive approach to doing this might be to call Sometimes it is more clear to split legend entries across multiple plot (,, label = 'test' ) for loc in : fig. subplots ( figsize = ( 6, 4 ), layout = 'constrained', facecolor = '0.7' ) ax. legend ( loc = loc, title = loc ) fig, ax = plt. plot (,, label = 'TEST' ) # Place a legend to the right of this smaller subplot. The legend is drawn outside the Axes on the (sub)figure. Specifying "outside" at the beginning of the loc keyword argument, Sometimes it makes more sense to place a legend relative to the (sub)figure legend ( bbox_to_anchor = ( 1.05, 1 ), loc = 'upper left', borderaxespad = 0. plot (, label = "test2" ) # Place a legend to the right of this smaller subplot. 102 ), loc = 'lower left', ncols = 2, mode = "expand", borderaxespad = 0. plot (, label = "test2" ) # Place a legend above this subplot, expanding itself to # fully use the given bounding box. subplot_mosaic (, ], empty_sentinel = "BLANK" ) ax_dict. Text rendering with XeLaTeX/LuaLaTeX via the pgf backendįig, ax_dict = plt.Customizing Matplotlib with style sheets and rcParams.Understanding the extent keyword argument of imshow.Tight layout guide (mildly discouraged).Writing a backend - the pyplot interface.Interactive figures and asynchronous programming.Matplotlib Application Interfaces (APIs). ![]() ![]() ![]() Choose from a wide range of icons, markers, and shapes and customize images and backgrounds Maintain a big-picture understanding without losing sight of critical details Visually connect topics to highlight relationships and dependencies Collect relevant files, links, images, and more-in one central place Add detailed information to topics, such as notes, properties, links, and attachments Get an at-a-glance view of where to focus your time and effort Enrich tasks with resource information, deadlines, notes, and other metadata Easily add, remove, and reprioritize topics Use MindManager Snap to send content and ideas directly to MindManager wherever you are and at whatever time of day Evolve a brainstorm into an executable strategy, process, or plan in the same application Add topics as quickly as you think of them Start a diagram from a blank slate or from one of 25+ pre-built templates Get started now with a free, full-featured 30-day trial. MindManager makes it easy for you to think more clearly, make better decisions, and do great work faster. Transform scattered ideas and data into dynamic visual maps, diagrams, flowcharts, matrices, and more. Enjoy the full-featured product and cancel at any time before the trial period is over-at no cost to you.Ĭapture, organize, manage, and share your business-critical information more easily, elegantly, and efficiently with MindManager mind mapping and visual work management software. Get your FIRST 30 DAYS FREE when you sign-up for a MindManager subscription. ![]() ![]() AV-1451 and AV-1451 were characterized in in vitro binding assays using recombinant and native proteins/tissues from postmortem samples of controls and Alzheimer's disease and PSP patients. The aim of the present study was to characterize the in vitro binding of AV-1451 to understand and identify potential off-target binding that could explain the poor discrimination observed in PSP patients. Moreover, accurate quantification of AV-1451 uptake in Alzheimer's disease may not be possible. Although results obtained in Alzheimer's disease patients are compelling, discrimination of tracer uptake in healthy individuals and patients with supranuclear palsy (PSP) is less clear as there is substantial overlap of signal in multiple brain regions. Lilly/Avid's AV-1451 is one of the most advanced tau PET tracers in the clinic. Vermeiren, Céline Motte, Philippe Viot, Delphine Mairet-Coello, Georges Courade, Jean-Philippe Citron, Martin Mercier, Joël Hannestad, Jonas Gillard, Michel The tau positron-emission tomography tracer AV-1451 binds with similar affinities to tau fibrils and monoamine oxidases. However, changes in surface electrostatic interactions sometimes changed the binding specificity of the designed peptides. Incorporating residues that favor helix formation into the designs increased binding affinities in all cases, providing low- nanomolar binders of each target. We have now measured the binding affinities and specificities of anti-bZIPs that bind to FOS, XBP1, ATF6, and CREBZF in solution and tested whether redesigning the surface residues can increase design-target affinity. High-throughput testing using peptide arrays indicated many successes. These "anti-bZIP" peptides were designed with an emphasis on target- binding specificity, with contributions to design-target specificity and affinity engineered considering only the coiled-coil core residues. Here we extend a prior study in which peptides were designed to bind tightly and specifically to representative members of each of 20 human bZIP families. However, folding studies on the model bZIP GCN4 show that coiled-coil surface residues also contribute to binding affinity. Previous work designing peptides to compete with native coiled-coil interactions focused primarily on designing the core residues of the interface to achieve affinity and specificity. This makes coiled coils attractive protein-protein interaction targets to disrupt using engineered molecules. The basic leucine-zipper (bZIP) transcription factors are one family of proteins for which coiled-coil mediated dimerization is essential for function, and misregulation of bZIPs can lead to disease states including cancer. The coiled-coil dimer is a prevalent protein interaction motif that is important for many cellular processes. Kaplan, Jenifer B Reinke, Aaron W Keating, Amy E Increasing the affinity of selective bZIP- binding peptides through surface residue redesign. Hence, high affinity tumor targeting and tunable albumin binding were combined in one small adaptable protein. The new affinity proteins competed for ERBB2- binding with the monoclonal antibody trastuzumab and recognized the native receptor on a human cancer cell line. Moreover, parallel selections against ERBB2 in the presence of human serum albumin identified several amino acid substitutions that dramatically modulate the albumin affinity, which could provide a convenient means to control the pharmacokinetics. Several affinity-matured molecules were shown to bind human ERBB2 with sub- nanomolar affinity while retaining the interaction with human serum albumin. Cell surface display and flow-cytometric sorting allowed stringent selection of top candidates from pools pre-enriched by phage display. Phage display selection against ERBB2 was used for identification of a lead candidate, followed by affinity maturation using second-generation libraries. In an attempt aimed at combining ERBB2-targeting with antibody-like pharmacokinetic properties in a small protein format, we have engineered bispecific ERBB2- binding proteins that are based on a small albumin- binding domain. However, small proteins and peptides generally suffer from fast excretion through the kidneys, and thereby require frequent administration in order to maintain a therapeutic concentration. In such strategies, the full-length antibody format is probably not required for therapeutic effect and smaller tumor-specific affinity proteins might be an alternative. Recent studies suggest that the over-expression of this receptor in various cancers might also be exploited for antibody-based payload delivery, e.g. The epidermal growth factor receptor 2, ERBB2, is a well-validated target for cancer diagnostics and therapy. ![]() Nilvebrant, Johan Ã…strand, Mikael Georgieva-Kotseva, Maria Björnmalm, Mattias Löfblom, John Hober, Sophia ![]() Engineering of Bispecific Affinity Proteins with High Affinity for ERBB2 and Adaptable Binding to Albumin ![]() ![]() ![]() ![]() ![]() A weekly global list of Netflix’s most watched. Christmas movies on Netflix to add to your to-watch list in 2022. Best Funny Christmas Movies to Deck Your Halls With Laughs - Netflix Tudum. But which princely offering is worth your time? Let this list be your guide for the top 20 Christmas films to stream on Netflix this year. funny Christmas movies, including favorites like Elf, National Lampoons. It’s a unique opportunity that allows me to learn the differences between Christmas with a Prince, A Prince for Christmas, and The Christmas Prince. One Magic Christmas (1985) Its a Wonderful Life usually gets all the spotlight when it comes to holiday guardian-angel movies, but this film also features a heavenly protector. Romantic Comedy Movies A Naija Christmas The Knight Before Christmas Let It Snow A California Christmas: City Lights Delivery by Christmas White Christmas. No one knows Christmas films more than a Jewish guy who spends the entire holiday season watching movies while everyone else wakes up early to open presents and entertain family. It follows a predictable plot consisting of a few individuals and friends busy sorting out their problems. Let it Snow (2019) This movie is about a group of young people brought together due to a snowstorm on Christmas eve. There’s even a whole genre dedicated just to cookie-cutter rom-coms centered around mistletoe season, and Netflix has caught on to the cheesy trend that was popularized by Hallmark and Lifetime.ĭon’t know where to begin as you scroll through endless holiday titles that all seem to look the same? That’s where I come in. Watch Trailer Watch the movie on Netflix. Sure, you could the same about Halloween, Valentine’s Day, or just about any commercialized holiday-but Christmas, especially, yields more movies than any other time of the year. ![]() ![]() ![]() These include tools for converting PDF files to Word, Excel, PowerPoint and JPEG. ![]() Smallpdf's free online PDF editing offering is super-basic, only making it possible to add minor changes to documents.īut you may find Smallpdf's other free features more compelling. All the other tools work as expected, including a signature tool that lets you sign a document using the keyboard, your mouse or an uploaded image. You can add a new text field to your document, enter new text and adjust the text, placing it anywhere you want on the document.īut there is no way to make changes to existing text, other than by redacting it. You have four fonts to choose from, but you can resize those fonts to almost any level you want, and you can also make changes to text colors and styles. Drag a file to your browser - there's a 10MB max size - then use FormSwift's tools to add new text and images highlight, redact or erase existing text and sign documents.įormSwift's text tools are limited. Or you can download blank versions of the documents and enter information locally on your computer.įor PDF editing, the process is simple. We found FormSwift's offerings to be excellent and well worth a look if you need basic business documents such as 1099s, lease agreements and business meeting minutes.Īll of these forms can be filled out online and downloaded once you've added the pertinent information. While it gives you the option to upload and edit PDF files, it also offers a large library of legal and other business forms you can fill in online and download as a PDF file or Word document. Preview is a solid option for basic PDF editing, and if you own a Mac, accessing Preview's powers is as simple as launching the app.įormSwift offers a slightly different twist on PDF editing. Those markup tools include text-selection options drawing tools you can use to add freehand drawings to a document a text tool for adding additional text to a document a tool that adds shapes and notes and a signature tool that you can use to capture your signature using your Mac's camera, a tablet or your trackpad. Preview's full set of markup tools appears when you click a small markup button that looks like a pencil tip located next to the search tool in the Preview toolbar. The bulk of Preview's markup capabilities aren't obvious when you first open the app, although you'll find a few basic tools for rotating pages and highlighting text on the basic toolbar. It is the multitool of the image-editing universe, capable of opening virtually any image file you may encounter. Not only is it capable for working with PDF files, but it also offers a number of other image-editing features. Apple's Preview application is built into every version of macOS. ![]() ![]()
![]() ![]() If you are a developer, then this is a must have free application. ![]() One part forum and one part collaborative work space, GitHub is the current and modern way for Microsoft to distribute code and facilitate the creation of scrips and code for their products. GitHub for Windows allows for easy access to the large and dynamic development environment that is GitHub. For RHEL-based distributions (such as Fedora, AlmaLinux, and Rocky Linux), the steps are: Install the GPG key: sudo rpm. Using tools shouldn't be hard, using GitHub to create and manage projects will make sure that you're focusing on the project and not worrying about the environment that you're using to develop in. Finally, install GitHub desktop with: sudo apt install github-desktop -y. the windows application brings these workflow threads together, making travelling the different areas of GitHub easy and intuitive. Since the GitHub is hosted in the cloud, reviewers and designers don't need to be in the same country, let alone the same room in order to share ideas and create together. By creating 'branches' to projects and using versioning controls, designers can easily make changes to a code base, submit it for approval to a reviewer and then have it approved and added to the main code project. it also gives code designers and reviews a host of tools to work on and improve code projects that are hosted on GitHub. The main reason to use GitHub for Windows is to have everything in all in one place. the Windows application brings all these various threads of utility together into one place on your windows desktop. GitHub has forum boards, chat rooms and shared work space to create and facilitate dynamic workflow in the modern work place. ![]() You can also post your own innovations, collaborate on projects and post questions. Need scripts to provision and configure a list of Microsoft Exchange mailboxes? You can find that on GitHub. need Azure network templates? GitHub has that. Recently, Microsoft Azure developers have been moving more and more resources to the internet and they use GitHub as their distribution point. True to it's name, GitHub is a hub where you can go to git things, specifically, resources, tools and information on how to install, manage and maintain all manner of Microsoft software and services. To understand what GitHub for Windows is, you need to understand the community that is GitHub. VPN.ht Desktop Application for Windows and Mac OS X built on top of Electron - GitHub - VPNht/desktop: VPN. Ergonomic, intelligent and backed by the technical knowledge of a community of Microsoft professions and Engineers, this is the app to have. All the great articles, scripts and tutorials that are available through the website brought together into one, naively installed and free, application. Gain access to the powerful technical community that is GitHub right form your Windows PC with GitHub for Windows. Softonic review A must have for developers and creators ![]() ![]() ![]() Thank Ran for his #CampCarePackage on Twitter, and check out his books on Bookshop. He currently serves on the faculty of Hampton University, where he teaches creative writing. Ran Walker is the author of twenty-one books and is the winner of the 2019 Indie Author of the Year and 2019 BCALA Fiction Ebook Awards. The process of editing and polishing your story into its final version can only happen once you start writing. You might even enjoy reading as many books on the craft of writing as possible to help you prepare, but the reality is that you have to eventually write something. It can be fun to outline your story or talk about aspects of the plot with your friends and family. “One of the best pieces of writing advice I ever received was this: you can’t edit a blank page. This week, author Ran Walker will be sending daily writing tips, encouragement, and inspiration directly to your NaNoMessages. ![]() □ Let the world know you’re participating in Camp NaNoWriMo this year by downloading some of our digital flair! (Writing a musical? We’ve got badges and banners for that, too.) Camp Care Packages from Published AuthorsĮvery Camp session, we assemble a team of published authors to bring you daily writing advice. □ Join our Virtual Write-In today, 1 PM PST ( Your Time Zone) to get a jumpstart on your Camp project and write with other Wrimos from around the world. □ You can now officially classify your Camp project as a musical! If you want to learn more about writing a musical, watch our Q&A webcast with your musical Camp Counselors. ![]() Once you’ve reached your writing goal, the site will automatically confirm your win, and you’ll receive a certificate celebrating your achievement, along with a bunch of other winner goodies!.Once you’ve done that, you should be ready to start tracking your project! You’ll be able to start tracking your writing at 12:01 AM on July 1 in your time zone!.To participate in Camp NaNoWriMo, just announce a project, then make sure to check “Associate with a NaNoWriMo event”, and select the current Camp NaNoWriMo event.But the gist of it remains the same: set your own writing goals, join an online writing group, and give yourself a creative retreat this spring! How can I participate in Camp NaNoWriMo? Join us for your next writing adventure!įor those of you who have participated before, Camp NaNoWriMo looks a little different this year, as we’re hosting it on the new site. To see more of Reesa’s collaboration with NaNoWriMo, you can check out our 2023 merch collection.Camp NaNoWriMo is your online writers’ retreat, designed to help you set and reach your personal writing goals. but you should still claim some bragging rights for your effort and hard work! Download and fill out our 2023 NaNoWriMo Writer certificate. If you participate in National Novel Writing Month and don't meet your goal, you won't get access to the winner page. This year’s artist, ReesaBoBeesa, leaned into this magic with bold colors, lively shapes, and curious critters.ĭeclare your writerly commitment all over social media with our 2023 NaNoWriMo Writer badge! NOW!įor NaNoWriMo 2023, we’re embracing the magic of fairy tales: talking animals, enchanted lands, unimagined possibilities glittering just around the corner, waiting to be discovered by the lucky storyteller. Hop into the forumsto chat prep with other NaNoers, especially the NaNo Prep forum!Īnd don't forget to declare your creative commitment with our super cute social media flairbelow! Skim through all the #NaNo Prepposts in the NaNoWriMo blog. Watch the "Novel Prep" playliston our YouTube channel for tips and advice. Participants begin writing on November first with a goal of completing a 50,000-word novel from scratch by the end of the month. ![]() Join a live NaNo Prep Virtual Write-Inor watch later to do the prompts and sprints on your own. National Novel Writing Month, also known as NaNoWriMo or simply NaNo, is a novel-writing challenge that takes place every November. (Note: this link will take you to a page on the site, but you don't have to be signed in or have an account to see it.) Follow along with us each week, or download the workbook to go at your own pace. Not sure what word-count goal to set? Check out our Word-Count Goal How-To!īrainstorm and plan with our Young Novelist Workbooks! (Educators, be sure to check out the curriculum and free classroom kits on the Teaching Resources page!)Ĭheck out the NaNo Prep 101 Workshop! We asked first-time NaNoWriMo winners what went right for them, and then used their answers to create this 6-week novel prep course, filled with activities and resources to help you plan your novel. September marks the official start of fall in the Northern Hemisphere, and the official start of NaNo Prep season all around the world! During September and October, we’ll provide resources to inspire, challenge, and prepare you to write that novel.įirst, accept the official NaNoWriMo challenge from your Dashboard! ![]() ![]() ![]() The scanning step can take a variable amount of time based on the recovery method chosen, with deep scans taking longer but providing more extensive recovery capabilities. 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